Maintaining a healthy gut is crucial for overall wellness as a balanced microbiome supports digestion, immune function, and metabolic health. Synbiotics are combinations of probiotics (beneficial gut bacteria) and prebiotics (non-digestible fibers that support their growth) working together synergistically in the digestive tract.1 Bacillus subtilis DE111®, a clinically tested probiotic, has been shown to effectively promote gut health by enhancing the balance of beneficial bacteria.
This blog delves into what makes DE111® a standout probiotic strain and explores the added benefits of naturally occurring prebiotics from fruit and citrus pectin, offering an effective combination that supports gut health, immune function, and the restoration of intestinal flora.
What Is DE111®?
DE111® is a clinically tested strain of Bacillus subtilis, a spore-forming probiotic known for its resilience in the human digestive system. Spore-forming probiotics like DE111® can survive extreme conditions, including the stomach's acidic environment. Unlike many probiotics that don’t survive this harsh journey, DE111® remains intact, germinating within four hours of ingestion and becoming metabolically active in the small intestine.2,3
Genomic Advantage: Recent genomic studies have uncovered several genes within DE111® that encode for acid and stress tolerance mechanisms. These adaptations enable DE111® to survive and thrive in challenging gastrointestinal environments2,3. Additionally, DE111®'s genomic makeup includes adhesion proteins, which enhance its ability to adhere to the gut lining, promoting a more extended residence and more effective colonization.2,3
Mechanism of Action
DE111®'s unique characteristics and clinical studies offer a deeper understanding of how it works within the body:
- Gastrointestinal Survival: Clinically tested Bacillus subtilis DE111® withstands stomach acid and bile, allowing it to reach the small intestine, where it germinates and becomes metabolically active.2,3
- Neurotransmitter Modulation: DE111® may help modulate neurotransmitter levels, such as acetylcholine, which plays a role in gut motility and gut barrier function.2
- Metabolic Support: DE111® supports metabolic health by promoting fat absorption and utilization in the small intestine while producing beneficial compounds like bacteriocins, SCFAs, and organic acids that help maintain a balanced gut microbiome.2
- Immune Modulation: DE111® promotes immune health by boosting key components like IgA to help regulate the body’s natural defenses. Studies show DE111® maintains balanced immune activity, aiding a faster immune response and enhancing overall resilience.2
Nutrient Synthesis and Production
One of DE111®'s remarkable abilities is its role in nutrient synthesis. This probiotic strain is involved in producing and metabolizing several key nutrients vital for overall health. DE111® assists in the synthesis of important B vitamins such as thiamine, riboflavin, pyridoxine, biotin, and folate, as well as vitamin K2 (menaquinone), which supports bone and cardiovascular health.2
Moreover, DE111® aids in producing seven amino acids, including five essential amino acids: threonine, tryptophan, methionine, leucine, and lysine. These amino acids are critical for protein synthesis, muscle recovery, and overall metabolic function.2
Prebiotics: Nature’s Gut-Nourishing Ingredients
While DE111® is a powerful probiotic, its effectiveness is enhanced when combined with prebiotics. Prebiotics are naturally occurring compounds that act as food and fuel for beneficial bacteria, helping them thrive in the gut. Among the most effective prebiotic sources are polyphenol-rich fruits and citrus pectin.4,5 For long-term digestive health, fruit-sweetened gummies that include probiotics and prebiotics provide a comprehensive approach to supporting gut health.
Polyphenols as Prebiotics: Polyphenols, found in fruits like apples, berries, and grapes, have been studied for their ability to modulate the gut microbiome. Approximately 90–95% of dietary polyphenols reach the colon, where the gut microbiota metabolizes them.5 They promote the growth of beneficial bacteria while suppressing harmful microbes, creating a more favorable environment for probiotics like DE111®.4 Polyphenols help support the gut barrier further enhancing digestive health and overall wellness.4,6
Citrus Pectin: Citrus pectin, a soluble fiber found in the cell walls of citrus fruits, is another potent prebiotic. Pectin promotes the growth of additional beneficial bacteria like Lactobacillus and Bifidobacterium, two strains that play a crucial role in digestive health.4 By stimulating the growth of these bacteria, pectin helps improve regular bowel movements, supports nutrient absorption, and reduces occasional digestive discomfort.4
Prebiotics like polyphenols and citrus pectin enhance the effectiveness of probiotics like Bacillus subtilis DE111®, creating a synergy that can promote a balanced gut microbiome and help restore intestinal flora for improved digestive and immune health.
DE111®'s Role Beyond Digestion: Supporting Immune Health and More
Bacillus subtilis DE111® doesn’t just support gut health—it has far-reaching effects on overall wellness. Studies show that DE111® promotes a balanced internal environment, helping maintain healthy skin, microbial balance, and comfort in sensitive areas of the body, providing microbiome balance for men and women’s health.2
Immune Resilience: DE111® supports immune function by enhancing IgA secretion and modulating immune markers, helping to strengthen the body’s natural defenses.2
Skin and Metabolic Benefits: DE111® promotes a balanced microbiome, supporting skin health and assisting in lipid metabolism for improved fat utilization.2
A Convenient and Delicious Way to Support Wellness
One of the biggest challenges in maintaining a daily probiotic regimen is compliance. Many probiotic supplements come in capsule or powder form, which can be inconvenient or unappealing for some. This is where combining Bacillus subtilis DE111® with prebiotics in a naturally sweetened fruit gummy shine.
Gummies offer a convenient, enjoyable way to ensure you get the daily support your body needs for gut health and immune function. Look for gummies that are naturally sweetened by 100% whole-fruit concentrates. These gummies make it easier and healthier to stick to a daily supplement routine. With no artificial flavors, colors, or preservatives, clean label probiotic gummies provide a convenient, natural solution that fits busy and health-conscious lifestyles.
Boosting Compliance
Compliance is critical to realizing the full benefits of any supplement, and the convenience of a tasty gummy significantly increases the likelihood that both adults and children will stick to their daily probiotic regimen. Look for the winning combination - a clinically tested probiotic with fruit-derived prebiotics in a naturally sweetened gummy makes it easier than ever to consistently support gut and immune health.4
The Synergy of DE111® and Prebiotics: A Foundation for Wellness
The combined power of a comprehensive probiotic with prebiotic for digestive health, like DE111® and naturally derived prebiotics. from fruit purees and citrus pectin offers a comprehensive approach to gut and immune health. By promoting a balanced microbiome, supporting digestive health, efficient digestion, and enhancing immune function, this synergistic combination provides an easy and effective way to maintain overall wellness.
Understanding the science behind probiotics and prebiotics is crucial for both health-conscious consumers and practitioners. DE111® has been extensively studied and clinically tested to offer significant digestive, immune, and metabolic benefits, while prebiotics from fruits and citrus pectin ensure that beneficial bacteria are supported and nourished.
A Conclusive Solution to Science-Backed Gut and Immune Support
Gut health is the cornerstone of overall wellness, and probiotics and prebiotics are at the forefront of supporting it. DE111®’s clinical evidence demonstrates its effectiveness in promoting digestive regularity, immune function, and metabolic balance.2,3 These benefits are amplified with prebiotic sources like polyphenol-rich fruit purees and citrus pectin. By choosing a synbiotic formulation that includes Bacillus subtilis DE111® with naturally occurring prebiotics, individuals benefit from a balanced gut microbiome, restored intestinal flora, and enhanced immune health for comprehensive wellness.
‡ The products and claims made about specific products on or through this Site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure, or prevent disease.
‡ This Site is not intended to provide diagnosis, treatment, or medical advice. Products, services, information, and other content provided on this Site, including information that may be provided directly or by linking to third-party websites are provided for informational purposes only. Please consult accredited healthcare professional organizations, evidence-based herbal monographs, and published clinical research regarding any medical or health-related diagnosis or treatment options.
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References
- Markowiak P, Śliżewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017;9(9):1021. Published 2017 Sep 15. doi:10.3390/nu9091021. Available at: https://pubmed.ncbi.nlm.nih.gov/28914794/
- Colom J, Freitas D, Simon A, et al. Acute physiological effects following Bacillus subtilis DE111 oral ingestion - a randomized, double blinded, placebo-controlled study. Benef Microbes. 2023;14(1):31-44. doi:10.3920/BM2022.0081. Available at: https://pubmed.ncbi.nlm.nih.gov/36790091/
- Mazhar S, Khokhlova E, Colom J, Simon A, Deaton J, Rea K. In vitro and in silico assessment of probiotic and functional properties of Bacillus subtilis DE111®. Front Microbiol. 2023;13:1101144. doi:10.3389/fmicb.2022.1101144. Available at: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1101144/full
- Molinari R, Merendino N, Costantini L. Polyphenols as modulators of pre-established gut microbiota dysbiosis: State-of-the-art. Biofactors. 2022;48(2):255-273. doi:10.1002/biof.1772. Available at: https://pubmed.ncbi.nlm.nih.gov/34397132/
- Plamada D, Vodnar DC. Polyphenols-Gut Microbiota Interrelationship: A Transition to a New Generation of Prebiotichttps://pubmed.ncbi.nlm.nih.gov/35011012/ s. Nutrients. 2021;14(1):137. Published 2021 Dec 28. doi:10.3390/nu14010137. Available at: https://pubmed.ncbi.nlm.nih.gov/35011012/
- Nazzaro F, Fratianni F, De Feo V, Battistelli A, Da Cruz AG, Coppola R. Polyphenols, the new frontiers of prebiotics. Adv Food Nutr Res. 2020;94:35-89. doi:10.1016/bs.afnr.2020.06.002. https://pubmed.ncbi.nlm.nih.gov/32892838/
Jenny Perez is an herbal educator, researcher, and writer who has been immersed in nutrition and botanical medicine for over twenty years. She has created curriculum, content, and educational materials for Premier Research Labs, Quantum Nutrition Labs, the American Botanical Council, and Bastyr University’s Botanical Medicine Department, where she was Adjunct Faculty, Herb Garden Manager, and Director of the Holistic Landscape Design certificate program.
